The company has been selected as 'preferred supplier' for the programme, to be run as a 50/50 venture with the DoH IT department.
Detailed negotiations must still be completed before the deal is signed, but the programme is expected to start in April next year.
The NHS Shared Financial Services Scheme was launched in April 2003 with the aim of saving up to £180m a year on administration costs.
Under the public-private partnership agreement with Xansa the two processing centres already operating in Yorkshire and the South West will be run as discrete self-funding businesses.
Xansa's shares rose 7.5p to 92.5p, following the news, having fallen to a low of 66p in August.
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